For Healthcare Professionals

Key Facts

Formulated for children and adults with developmental, gastrointestinal, or behavioral issues that limit broad food choices or who have special nutritional needs or food sensitivities, and for use with gluten-free/casein-free diets.
Contains important antioxidants that reduce oxidative stress in the body and support the immune system*
Contains MSM and N-acetyl-cysteine, which are sources of sulfur that support normal sulfation pathways*
Contains adequate doses of B vitamins, folate and folinic acid, and minerals to support normal methylation pathways*
Supports the body’s natural detoxification pathways*
Safely and effectively increases levels of fat-soluble nutrients and antioxidants*
A Biomedical Clinical Study showed improvements in many biomedical pathways including improvement in neurotransmitter levels, glutathione, and plasma ATP1
Documented safety profile1
Syndion combines an optimal combination of ingredients with a microsphere technology that enhances the absorption of the fat-soluble nutrients*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent disease.

Reference: 1. Data on file. Yasoo Health Inc.

Syndion & Syndion-SF Fact Sheet

Biomedical Clinical Study Overview

Syndion-SF Product Label

Pharmacology

Many children and adults do not consume appropriate amounts of vitamins and antioxidants that are important to maintain health and prevent deficiency. Nutritional deficiencies may be exacerbated by restrictive diets, poor digestion, chronic diarrhea, and intestinal bacterial overgrowth. Deficiencies of one or more fat-soluble vitamins may occur in individuals whose diets are deficient in these vitamins or who, for any number of reasons, have difficulty in absorbing fat from their diets. Any condition that diminishes the function of the pancreas, the liver, or the digestive system can cause malabsorption. Fat-soluble vitamins and minerals can only be absorbed after they are incorporated into micelles through the actions of the body’s bile and pancreatic secretions. These micelles are spherical particles that have lipophilic (fat-loving) interiors encapsulated by hydrophilic (water-loving) exteriors that facilitate absorption of fat-soluble vitamins in the body.*

Make sure your patients are actually absorbing the fat-soluble vitamins and nutrients you strive to ensure they are receiving!

Microsphere technology forms
micellar structures that aid in
vitamin and micronutrient
absorption.

The absorption technology used in Syndion is the same technology as is used in our AquADEKs vitamin product for Cystic Fibrosis and is illustrated by this graphic demonstrating the difference in absorption compared to another product.

This absorption technology is supported by published articles showing increased absorption in malabsorbing patient populations. View publications here

James B. Adams, Ph.D, researcher at Arizona State University, conducted the clinical studies on Syndion.

(Dr. Adams is not affiliated with Yasoo Health and does not benefit financially from Syndion sales). To visit Dr. Adams's research website, click here.

2010 Articles of Interest:

Priya L, Geetha A. Level of Trace Elements (Copper, Zinc, Magnesium and Selenium) and Toxic Elements (Lead and Mercury) in the Hair and Nail of Children with Autism. Biol Trace Elem Res. 2010 Jul 13. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/20625937

Bradstreet JJ, Smith S, Baral M, Rossignol DA. Biomarker-guided interventions of clinically relevant conditions associated with autism spectrum disorders and attention deficit hyperactivity disorder. Altern Med Rev 2010 Apr;15(1):15-32.

http://www.ncbi.nlm.nih.gov/pubmed/20359266

Woods JS, Armel SE, Fulton DI, Allen J, Wessels K, Simmonds PL, Granpeesheh D, Mumper E, Bradstreet JJ, Echeverria D, Heyer NJ, Rooney JP. Urinary Porphyrin Excretion in Neurotypical and Autistic Children. Environ Health Perspect 2010 Jun 24. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/20576582

"the micronutrient group's improvement was significantly greater" "There are some advantages to treatment with micronutrients - lower activity level, less social withdrawal, less anger, better spontaneity with the examiner, less irritability, lower intensity of self-injurious behaviors, markedly fewer adverse events, and less weight gain."

Mehl-Madrona L, Leung B, Kennedy C, Paul S, Kaplan BJ. Micronutrients versus standard medication management in Autism: A Naturalistic Case-Control Study. J Child Adolesc Psychpharmacol. 2010 Apr; 20(2):95-103. http://www.ncbi.nlm.nih.gov/pubmed/20415604

"It is therefore important that children with autism should be regularly monitored for nutritional status and dietary intake. In addition, parents and guardians of autistic children should be provided with accurate nutritional information and should be encouraged to diversify the diet of their child or otherwise rectify the deficiencies identified here through appropriate supplementation with vitamins and minerals."

Xia W, Zhou Y, Sun C, Wang J, Wu L. A preliminary study on nutritional status and intake in Chinese children with autism. Eur J Pediatrics 2010 Apr 27 [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/20422215

Cermak SA, Curtin C, Bandini LG. Food selectivity and sensory sensitivity in children with autism spectrum disorders. J Am Diet Assoc. 2010 Feb;110(2):238-46. http://www.ncbi.nlm.nih.gov/pubmed/20102851

Kern JK, Geier DA, Adams JB, Geier MR. A biomarker of mercury body-burden correlated with diagnostic domain specific clinical symptoms of autism spectrum disorder. Biometals. 2010 Jun 9. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/20532957

Yorbik O, Kurt I, Haşimi A, Oztürk O., Chromium, cadmium, and lead levels in urine of children with autism and typically developing controls. Biol Trace Elem Res. 2010 Jun;135(1-3):10-5. Epub 2009 Aug 18. http://www.ncbi.nlm.nih.gov/pubmed

2009 Articles of Interest:

James SJ, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW. Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. Am J Clin Nutr. 2009 Jan;89(1):425-30. http://www.ncbi.nlm.nih.gov/pubmed/19056591

Herndon AC, DiGuiseppi C, Johnson SL, Leiferman J, Reynolds A. Does nutritional intake differ between children with autism spectrum disorders and children with typical development? J Autism Dev Disord. 2009 Feb;39(2):212-22. Epub 2008 Jul 4. http://www.ncbi.nlm.nih.gov/pubmed/18600441

2008 Articles of Interest:

Lockner DW, Crowe TK, Skipper BJ. Dietary intake and parents' perception of mealtime behaviors in preschool-age children with autism spectrum disorder and in typically developing children. J Am Diet Assoc. 2008 Aug;108(8):1360-3..http://www.ncbi.nlm.nih.gov/pubmed/18656577

Evans C, Dunstan RH, Rothkirch T, Roberts TK, Reichelt KL, Cosford R, Deed G, Ellis LB, Sparkes DL. Altered amino acid excretion in children with autism. Nutr Neurosci. 2008 Feb;11(1):9-17. http://www.ncbi.nlm.nih.gov/pubmed/18510798

Lakhan SE, Vieira KF. Nutritional therapies for mental disorders. Nutr J. 2008 Jan 21;7:2. http://www.ncbi.nlm.nih.gov/pubmed/18208598

Geier DA, Kern JK, Garver CR, Adams JB, Audhya T, Geier MR. A prospective study of transsulfuration biomarkers in autistic disorders. Neurochem Res. 2009 Feb;34(2):386-93. Epub 2008 Jul 9. http://www.ncbi.nlm.nih.gov/pubmed/18612812

Curtis LT, Patel K. Nutritional and environmental approaches to preventing and treating autism and attention deficit hyperactivity disorder (ADHD): a review. J Altern Complement Med. 2008 Jan-Feb;14(1):79-85. http://www.ncbi.nlm.nih.gov/pubmed/18199019?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Previous Articles of Interest:

Adams JB, Holloway C. Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder. J Altern Complement Med. 2004 Dec;10(6):1033-9. http://www.ncbi.nlm.nih.gov/pubmed/15673999

Aldred S, et al. Plasma amino acid levels in children with autism and their families. J Autism Dev Disord. 2003 Feb;33(1):93-7. http://www.ncbi.nlm.nih.gov/sites/pubmed

Arnold GL et al. Plasma amino acids profiles in children with autism: potential risk of nutritional deficiencies. J Autism Dev Disord 2003 33(4):449-54. http://www.ncbi.nlm.nih.gov/sites/pubmed

Baker SB, Worthley LI. The essentials of calcium, magnesium and phosphate metabolism: part I. Physiology. Crit Care Resusc. 2002 Dec;4(4):301-6. http://www.ncbi.nlm.nih.gov/pubmed/16573443

Carlton R et al. Rational dosages of nutrients have a prolonged effect on learning disabilities. Alternative Therapies2000; 6:85-91. http://www.ncbi.nlm.nih.gov/sites/pubmed

James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr. 2004 Dec;80(6):1611-7. http://www.ncbi.nlm.nih.gov/pubmed/15585776

Mousain-Bosc M, Roche M, Polge A, Pradal-Prat D, Rapin J, Bali JP. Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. II. Pervasive developmental disorder-autism. Magnes Res. 2006 Mar;19(1):53-62. http://www.ncbi.nlm.nih.gov/pubmed/16846100 & http://www.ncbi.nlm.nih.gov/pubmed/16846101

Mousain-Bosc M, Roche M, Rapin J, Bali JP. Magnesium VitB6 intake reduces central nervous system hyperexcitability in children. J Am Coll Nutr. 2004 Oct;23(5):545S-548S. http://www.ncbi.nlm.nih.gov/sites/pubmed

Shoenthaler S et al. The effect of vitamin-mineral supplementation on the intelligence of American schoolchildren: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med 2000;6:19-29. http://www.ncbi.nlm.nih.gov/sites/pubmed

Walsh WJ, et al. Reduced violent behavior following biochemical therapy. Physiol Behav. 2004 Oct 15;82(5):835-9. http://www.ncbi.nlm.nih.gov/sites/pubmed

Whiteley P, et al. Spot urinary creatinine excretion in pervasive developmental disorders. Pediatr Int. 2006 Jun;48(3):292-7. http://www.ncbi.nlm.nih.gov/sites/pubmed

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For more information, call us at 877-SYNDION (877-796-3466) or e-mail us at info@syndion.com.